Methylenetetrahydrofolate reductase gene polymorphism in type 1 diabetes mellitus: Relationship to microvascular complications
نویسندگان
چکیده
منابع مشابه
Plasma total homocysteine levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus.
BACKGROUND Thrombotic episodes account for approximately 80% of deaths in type 2 diabetic patients. Hyperhomocysteinaemia is a well recognized independent risk factor for atherosclerosis and thromboembolism. Increased homocysteine levels may occur due to a number of factors including inherited gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T. Here, we evaluate plas- ma tot...
متن کاملMethylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus
OBJECTIVE This review aimed to comprehensively assess the literature examining a possible link between the rs1801133 polymorphism (677C → T) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) gene and risk of type 2 diabetes mellitus (DM). RESEARCH DESIGN AND METHODS Several research databases were systematically searched for studies examining the genotype at the rs1801133 p...
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We examined whether alterations in vascular endothelial function and early structural changes in atherosclerosis are associated with microvascular complications in patients with type 1 diabetes mellitus (DM). Flow-mediated dilation (FMD) of the brachial artery and carotid intima-media thickness (IMT) measurement were performed in 70 young adults (aged 19 to 35 yr), 48 with type 1 DM, and 22 nor...
متن کاملMicrovascular Complications in Adolescents with Type 1 Diabetes Mellitus
OBJECTIVE Screening of complications is an important part of diabetes care. The aim of this study was to investigate diabetic complications and related risk factors in adolescents with type 1 diabetes mellitus (T1DM). METHODS This cross-sectional study was conducted on type 1 diabetics who were over 11 years of age or had a diabetes duration of 2 years and included 155 adolescents with T1DM (...
متن کاملMicrovascular complications of type 2 diabetes mellitus
BACKGROUND AND OBJECTIVES: It has been shown in studies that there are significant variations in glycation of various serum proteins in type 2 diabetes mellitus patients with and without microvascular complications. Present study aimed to evaluate whether correcting serum fructosamine for serum total protein level, serum glycated albumin for serum albumin level and deriving ratio of glycated β-...
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ژورنال
عنوان ژورنال: Egyptian Journal of Medical Human Genetics
سال: 2012
ISSN: 1110-8630
DOI: 10.1016/j.ejmhg.2012.03.010